Analyses Do Not Support CYP17 Genotype-Estradiol Associations

Analyses do not support CYP17 genotype-estradiol associations.

Distinguishing Mediational Models and Analyses in Clinical Psychology: Atemporal Associations Do Not Imply Causation.

PURPOSE A popular way to attempt to discern causality in clinical psychology is through mediation analysis. However, mediation analysis is sometimes applied to research questions in clinical psychology when inferring causality is impossible. This practice may soon increase with new, readily available, and easy-to-use statistical advances. Thus, we here provide a heuristic to remind clinical psy...

CYP17 genotype and ovarian cancer: a null case-control study.

Introduction Long-term differences in steroid hormone levels between women likely contribute to the interindividual variation in ovarian cancer risk, although the precise biological mechanisms are unclear (1). The P450c17a (CYP17) gene codes for 17ahydroxylase and 17,20 lyase which catalyze the rate-limiting step in androgen biosynthesis, cleaving the C21 steroids to the C19 steroids, androsten...

CYP17 genotype predicts serum hormone levels among pre-menopausal women.

BACKGROUND CYP17, which encodes cytochrome P450c17alpha, mediates both steroid 17alpha-hydroxylase and 17,20-lyase activities, and is essential for the production of glucocorticoids and sex steroids. There is evidence that a common polymorphism in CYP17 (T27C) is associated with estrogen levels, making it a potential marker of disease risk. METHODS This is the first study to examine the relat...

Replicating genotype–phenotype associations

NCI-NHGRI Working Group on Replication in Association Studies The study of human genetics has recently undergone a dramatic transition with the com­ pletion of both the sequencing of the human genome and the mapping of human haplo­ types of the most common form of genetic variation, the single nucleotide polymorphism (SNP). In concert with this rapid expansion of detailed genomic information, c...